Detection of proteases and screening for protease inhibitors
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Dec 1, 2005
app pub date -
May 5, 2003
filing date -
Nov 7, 2000
priority date (Note) -
Abandoned
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Abstract
The present disclosure provides a method for detecting a protease, which is simple, sensitive, and capable of high throughput. The method detects a protease in a sample by measuring lysis of a liposome due to activation of a modified or inactive channel-forming agent. Also disclosed is a method for screening a test compound, to determine if the test compound can function as protease inhibitor. A method for identifying a protease cleavage site is also disclosed.
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