Solid-phase capture-release-tag methods for phosphoproteomic analyses
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United States of America Patent
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Issued Date -
Nov 24, 2005
app pub date -
Feb 14, 2005
filing date -
Feb 13, 2004
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Abandoned
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Abstract
One aspect of the present invention relates to a method of labeling a peptide or protein comprising a phosphorylated amino acid comprising: a) removing from the peptide or protein the phosphate group via a .beta.-elimination to form a double bond conjugated to a C.dbd.O group; b) reacting the double bond from step a) with a nucleophile comprising a tag on a solid support; and c) removing the solid support from the product of step b) forming the labeled peptide or protein. A second aspect of the invention relates to a solid support comprising a linker and tag between the solid support and a nucleophile, wherein the tag comprises a label.
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