Peptides that deliver antisense oligonucleotides which downregulate protein expression in cells
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United States of America Patent
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app pub date -
Mar 15, 2005
filing date -
Nov 2, 2001
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Abandoned
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Abstract
The present invention provides a peptide that can complex with an oligonucleotide, e.g. an antisense oligonucleotide, and deliver it into a cell. The present invention also provides compositions comprising a complex of such a peptide and an oligonucleotide and methods of delivering an oligonucleotide into a cell and of inhibiting protein expression using such compositions. The present invention also provides a method of making such a complex, a method of sensitizing cells to anti-cancer agents such as paclitaxel, and pharmaceutical compositions.
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