Method of quantifying the cell-binding properties of a medical device
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United States of America Patent
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Issued Date -
Nov 24, 2005
app pub date -
May 2, 2005
filing date -
May 21, 2004
priority date (Note) -
Abandoned
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Abstract
The invention provides a method for quantifying the cell-binding properties of a medical device. In practicing the method, a medical device having at least one type of binding agent is incubated with cells expressing a ligand having an affinity for the binding agent on the medical device. The cells that bind to the medical device are labeled with at least one marker. The marker is detected, and the quantity of cells bound to the medical device is determined. Alternatively, labeled cells having at least one type of ligand expressing an affinity for the at least one type of binding agent may be provided that are incubated with the medical device. The relative expression of the ligand on the cell line having an affinity for the binding agent is also determined. The method can be used to assess, in vitro, how well cells will bind to the medical device, thereby providing useful insight as to the effectiveness of the medical device to promote cell adherence to the device, prior to in vivo implantation of such devices.
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