Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
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United States of America Patent
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Issued Date -
Nov 17, 2005
app pub date -
Jul 11, 2005
filing date -
Dec 10, 1998
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Abstract
A preparation comprising a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the action of the nucleotide synthesis inhibitors with a displacement in time, and a nucleotide synthesis inhibitor such as brequinar, mycophenolatemofetil (2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-- 4-methyl-4-hexenoate), methotrexate, mizoribine and compounds of formulae (I) and (II) 1 is suitable for the treatment of immunological disorders, cancer, or in transplantations.
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