Gene knock-down by intracellular expression of aptamers

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United States of America Patent

APP PUB NO 20050250106A1
SERIAL NO

10831632

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Abstract

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Materials and methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development.

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Patent Owner(s)

Patent OwnerAddress
ARCHEMIX CORP300 THIRD STREET FIRST FLOOR CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Epstein, David Belmont, MA 61 858
Marsh, Harold Nicholas Charlestown, MA 3 11
Pendergrast, Shannon Cambridge, MA 4 111
Thompson, Kristin Arlington, MA 13 341

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