Permeation enhancer comprising genus Curcuma or germacrone for transdermal and topical administration of active agents
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United States of America Patent
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Issued Date -
Nov 3, 2005
app pub date -
Apr 26, 2005
filing date -
Apr 30, 2004
priority date (Note) -
Abandoned
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Abstract
A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus Curcuma of the family Zingiberaceae, a germacrone, or a natural or synthetic constituent thereof, which has been found to increase penetration of the active agent across the dermal or mucosal surface. If desired, a secondary permeation enhancer of a polyalcohol, a monoalkyl ether of diethylene glycol, a tetraglycol, or a mixture thereof can be used for certain active agents for optimal permeation enhancement.
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