Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2
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United States of America Patent
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Issued Date -
Oct 27, 2005
app pub date -
Apr 25, 2005
filing date -
Apr 23, 2004
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Abandoned
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Abstract
The present invention provides a method of increasing or maintaining blood concentrations of 1,25-dihydroxyvitamin D in a patient by administering an amount of 1.alpha.-hydroxyvitamin D.sub.2. The invention also provides a method of concurrently lowering or maintaining plasma intact parathyroid hormone levels, increasing or maintaining serum calcium levels, maintaining serum phosphorous levels, or increasing or maintaining serum 1,25-dihydroxyvitamin D levels in a human patient by administering to the patient an amount of 1.alpha.-hydroxyvitamin D.sub.2. The invention also provides a method of reducing the risk of over suppression of plasma intact parathyroid hormone levels in a patient undergoing treatment for elevated levels of plasma intact parathyroid hormone, by administering 1.alpha.-hydroxyvitamin D.sub.2 in an amount sufficient to decrease elevated intact parathyroid hormone levels while avoiding an abnormally low bone turnover rate.
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