Stable injectable compositions
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United States of America Patent
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Issued Date -
Oct 27, 2005
app pub date -
Nov 30, 2004
filing date -
Mar 10, 2004
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
This invention relates to a stable parenteral aqueous solutions comprising either (a) diclofenac or a pharmaceutically acceptable diclofenac salt and a cyclodextrin, or (b) an inclusion complex of diclofenac or a pharmaceutically acceptable diclofenac salt and a cyclodextrin, or a mixture of (a) and (b), which are suitable for intramuscular and intravenous administration. The solutions contain diclofenac or diclofenac salt, cyclodextrin, and an antioxidant selected from monothioglycerol, or a combination of ethylene diamine tetra-acetic acid and N-acetyl-cysteine.
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