Facile synthesis of symmetric esters of alkylenebisphosphonic acids
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United States of America Patent
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app pub date -
May 25, 2005
filing date -
Apr 11, 2001
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Abstract
A facile synthesis of symmetric esters of C.sub.1-C.sub.10 alkylenebisphopsphonic acids is disclosed in which a C.sub.1-C.sub.10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C.sub.1-C.sub.10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C.sub.1-C.sub.10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.
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