Detection of antibodies to gangliosides using solid-phase reactants coated with carbonyl groups
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United States of America Patent
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app pub date -
Oct 18, 2004
filing date -
May 5, 2000
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Abstract
Methods of detecting antibodies to one or more ganglioside(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached thereon, and the ganglioside(s) of interest linked to the solid-phase reactant by an amide bond between an amino group of the ganglioside of interest and a carbonyl group attached to the solid-phase reactant. The methods of detecting antibodies to ganglioside(s) of interest can be used in methods of diagnosing neuropathies in an individual.
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