11-Beta hydroxysteroid dehydrogenase type 1 inhibitors as anti-obesity/anti-diabetes compounds and 17-beta hydrosteroid dehydrogenase type I inhibitors as useful agents for the treatment of cancers, especially breast cancer
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United States of America Patent
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Issued Date -
Oct 13, 2005
app pub date -
Mar 30, 2005
filing date -
Apr 8, 2004
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Abstract
This invention is directed to the discovery that 11-Beta Hydroxysteroid Dehydrogenase Type 1 may be a common molecular etiology for visceral obesity and the metabolic syndrome of obesity as well a treatment for diabetes, especially type II diabetes. The present invention also relates to the use of certain compounds as inhibitors of 17-Beta Hydroxysteroid Dehydrogenase Type 1 and their use for the treatment of cancer, especially breast cancer.
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