Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
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United States of America Patent
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Issued Date -
Oct 13, 2005
app pub date -
Dec 6, 2004
filing date -
Apr 27, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (.alpha.v) integrins, for example .alpha..sub.v.beta..sub.3 and .alpha..sub.v.beta..sub.5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by .alpha..sub.v.beta..sub.3 and .alpha..sub.v.beta..sub.5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula I: 1 where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, m, n, i, j and k are defined herein.
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