Methods for the identification of inhibitors of adenylosuccinate synthase as antibiotics
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United States of America Patent
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Issued Date -
Oct 13, 2005
app pub date -
Jan 13, 2005
filing date -
Jan 13, 2004
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Abstract
The present inventors have discovered that adenylosuccinate synthase is essential for normal fungal pathogenicity. Specifically, the inhibition of adenylosuccinate synthase gene expression in fungi results in drastically reduced pathogenicity. Thus, adenylosuccinate synthase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit adenylosuccinate synthase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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