Decoy for treating and/or preventing th2 cytokine-associated allergic disease, gata3 mutant protein and medicinal compositions containing the same
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United States of America Patent
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Issued Date -
Oct 6, 2005
app pub date -
Apr 28, 2005
filing date -
Apr 24, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention provides GATA3 decoys and GATA3 mutant proteins which can specifically suppress Th2 cytokine production and pharmaceutical compositions comprising such decoys and mutant proteins. This suppression is achieved by inhibiting binding of the GATA3 protein to the low affinity GATA3 binding sequence within the Th2 cytokine gene cluster, which causes suppression of the chromatin remodeling required for stable and sufficient expression of Th2 cytokines.
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