Compounds and methods for modulating VE-cadherin-mediated function
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United States of America Patent
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app pub date -
Dec 3, 2004
filing date -
May 5, 1998
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Abstract
Compositions and methods for modulating VE-cadherin-mediated functions are provided. The compositions and methods employ VE-cadherin modulating agents which generally comprise one or more of: (a) a peptide sequence that is at least 50% identical to a VE-cadherin cell adhesion recognition sequence; (b) a non-peptide mimetic of a VE-cadherin cell adhesion recognition sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a VE-cadherin cell adhesion recognition sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a VE-cadherin cell adhesion recognition sequence or analogue thereof.
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