Apoptosis promoter and inhibitor interacting with cgi-94, and method of screening the same
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United States of America Patent
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Issued Date -
Oct 6, 2005
app pub date -
Jun 30, 2003
filing date -
Feb 19, 2002
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Abstract
The present invention provides substances which suppress or promote apoptosis of nerve cells, methods for screening them, and methods for diagnosis and treatment of diseases associated with apoptosis and kits therefore. Specifically, the present invention provides suppress or promote functions of CGI-94 protein or the interaction of CGI-94 protein with Smac/DIABLO to suppress or promote apoptosis. In addition, the present invention also provides a p18TFP protein and its coding DNA as an apoptosis suppressing substance, and pharmaceutical compositions for treating diseases associated with apoptosis, which comprises said protein or DNA.
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