Use of indanoyl amide to stimulate secondary metabolism in Taxus sp.

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United States of America Patent

APP PUB NO 20050221456A1
SERIAL NO

11056396

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Abstract

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The invention is directed to a method for the production of taxanes by culturing suspension cells of Taxus sp. in a nutrient medium that comprises an indanoyl amino acid. The indanoyl amino acid may be added in batch mode or in a feed stream at any time of the culturing. In particular, synthetic compounds 6-Ethyl-indanoyl-isoleucine, 6-Bromoindanoyl isoleucine and 1-oxo-indane-carboxy-(L)-Isoleucine-methyl ester amide (1-OII) have been found to increase taxane production from Taxus cell cultures.

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Patent Owner(s)

Patent OwnerAddress
PHYTON HOLDINGS LLC2711 CENTERVILLE ROAD SUITE 400 WILMINGTON DE 19808

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alford, Jennifer Ithaca, NY 6 1
Heckenmuller, Harald Hamburg, DE 8 262
Roach, Braden Trumansburg, NY 4 33
Srinivasan, Venkatesh Sunnyvale, CA 53 562

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