Methods for the identification of inhibitors of amidophosphoribosyltransfe-rase as antibiotics
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United States of America Patent
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Issued Date -
Oct 6, 2005
app pub date -
Oct 20, 2004
filing date -
Oct 23, 2003
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Abandoned
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Abstract
The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit amidophosphoribosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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