Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
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United States of America Patent
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Issued Date -
Sep 29, 2005
app pub date -
Oct 4, 2004
filing date -
Apr 16, 2002
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Abandoned
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Abstract
1The present invention relates to a stable liquid preparation comprising a camptothecin derivative which is prepared by binding a compound of the formula [I]: wherein R.sub.1 is a substituted or unsubstituted lower alkyl group, X.sub.1 is a group of the formula: --NHR.sub.2 (R.sub.2 is a hydrogen atom or a lower alkyl group) or a hydroxy group and Alk is a straight or branched chain alkylene group optionally interrupted by an oxygen atom, and a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable sat thereof, which is adjusted to pH 5-8, or a stable pharmaceutical composition produced by lyophilizing said liquid preparation.
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