Compositions and methods for determining epistatic relationships between HIV mutations that affect replication capacity

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20050214752A1
SERIAL NO

11092204

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to methods for predicting replication capacity of a virus based on its genotype. It also relates to determining epistatic relationships between viral mutations, including those that affect replication capacity. It also relates to identifying targets for antiviral therapy by identifying mutations associated with altered replication capacity. The methods are useful for determining the replication capacity of an HIV based on its genotype and for identifying previously unknown interactions among viral molecules or between viral molecules and host cell molecules that are essential to viral infection and/or replication. By identifying such interactions, novel targets for antiviral therapy can be identified.

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Patent Owner(s)

Patent OwnerAddress
PFIZER INC66 HUDSON BOULEVARD EAST NEW YORK NY 10001

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bonhoeffer, Sebastian Zurich, CH 2 4

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