Method for nonsurgical treatment of the nucleus pulposus of the intervertebral disc using genipin or proanthrocyanidin, and kit therefor
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United States of America Patent
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app pub date -
Mar 29, 2005
filing date -
Mar 19, 2002
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Abandoned
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Abstract
This invention relates to a method and compositions for treating pathological intervertebral discs comprising the step of delivering an agent selected from the group consisting of genipin and proanthrocyanidin that causes chemical crosslinking of the native molecular components of the nucleus pulposus of the disc. Supplemental materials which are susceptible to crosslinking by the aforementioned agent are optionally delivered to the disc in order to increase and maintain disc height.
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