Targeted delivery of RNA interference molecules
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United States of America Patent
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Issued Date -
Sep 15, 2005
app pub date -
Feb 22, 2005
filing date -
Feb 20, 2004
priority date (Note) -
Abandoned
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Abstract
Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.
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