Importance

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Abstract

Methods, apparatus, and compositions calibrate a bio-photonic scanner detecting selected molecular structures of tissues, nondestructively, in vivo. The apparatus may include a processor, memory, and scanner. The scanner directs light nondestructively onto tissue in vivo, then receives back a radiant response through a system of mirrors and lenses back into the detector. Software for controlling the scanner and processing its output may be calibrated using a synthetic material to mimic the radiant response of tissue. Calibration may account for background fluorescence and elastic scattering, mimicking skin tissue materials having substantially no Raman scattering response of interest. Dopants may be added to the matrix of white scan material to mimic selected molecular structures in tissue. Matrix materials include a dilatant compound, and dopants include biological materials as well as K-type polarizing film and other materials.

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First Claim