Novel compositions of saponin adjuvants and excipients
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United States of America Patent
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Issued Date -
Sep 1, 2005
app pub date -
Oct 3, 2003
filing date -
Aug 29, 1997
priority date (Note) -
Abandoned
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Abstract
Certain novel compositions of the adjuvant saponin QS-21 having improved properties are disclosed. The compositions of the present invention are designed (1) to minimize the lytic effects of QS-21, (2) to improve the tolerance of QS-21 containing formulations in humans or other animals, (3) to stabilize the QS-21 from alkaline hydrolysis and/or (4) to maintain the high adjuvant potency of the QS-21 product. These compositions may be employed with vaccines comprising proteins or peptides, polysaccharides, lipids, or nucleic acids.
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