Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative

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United States of America Patent

APP PUB NO 20050187264A1
SERIAL NO

10510053

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Abstract

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This invention relates to a phosphodiesterase IV inhibitor containing as an active ingredient a pyridylacrylamide derivative represented by the following formula (I): 1 (wherein Ar.sup.1 represents substituted or unsubstituted pyridyl; Ar.sup.2 represents phenyl substituted by alkoxy, etc.; R.sup.1 represents hydrogen, alkyl, or aryl; R.sup.2 represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R.sup.3 represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each independently represents hydrogen, hydroxyl, alkoxy, or alkylthio, or A and B together represent oxo, thioxo, etc., or A may be hydroxyl and B may be 1-alkylimidazol-2-yl; and n is an integer from 1 to 3) or a pharmaceutically acceptable salt thereof.

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Patent Owner(s)

Patent OwnerAddress
TSUMURA & CO2-17-11 AKASAKA MINATO-KU TOKYO 107-8521

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hasegawa, Yoshihiro Ibaraki, JP 27 221
Hattori, Tomohisa Ibaraki, JP 6 10
Obata, Tatsuhiro Ibaraki, JP 3 10
Sasaki, Toshinobu Ibaraki, JP 3 70

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