Process for the production of alpha-l-aspartyl-l-phenylalanine methyl ester powder
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United States of America Patent
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Issued Date -
Aug 25, 2005
app pub date -
Oct 7, 2004
filing date -
Sep 14, 2001
priority date (Note) -
Abandoned
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Abstract
The invention relates to a process for the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester (APM) powder wherein the upper limit of the particle size distribution (p.s.d.) of the powder, expressed as the d.sub.99, is controllable, wherein an APM starting material, comprising at least 5 wt % of APM particles larger than the d.sub.99 of the APM powder to be obtained, is subjected to treatment in at least one roller mill, each such roller mill comprising at least one roller pair, each roller pair consisting of two smooth rollers of which at least one is rotating such that the APM starting material, or APM intermediate powder for any second or further roller mill, is transported into the roller gap of said roller mill. The invention also relates to an APM powder with a d.sub.99 of <500 .mu.m produced by the process according to the invention and the use of said APM powder for the production of tablets by direct compression.
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