Aptamers and antiaptamers
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United States of America Patent
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Issued Date -
Aug 11, 2005
app pub date -
Sep 17, 2004
filing date -
Jun 29, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention relates to: An aptamer comprising a circular oligonucleotide defining one to four target binding regions; An aptamer comprising an oligonucleotide defining two, three or four thrombin binding quadruplex regions separated by at least partially duplex regions, wherein the quadruplex regions comprise a GGTMGGXGGTTGG sequence wherein M represents A or T and X represents a sequence of two to five nucleotides and/or nucleotide analogues; An aptamer represented by formula (I): 5'D.sub.1, wQxD.sub.1D.sub.2yQzD.sub.2,3'--the variables are as defined in the specification; and Aptamers selected from specific sequences.
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