RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)

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United States of America Patent

APP PUB NO 20050176663A1
SERIAL NO

10897902

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Abstract

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This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of protein tyrosine phosphatase type IVA (PRL3) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of protein tyrosine phosphatase type IVA (PRL3) genes.

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SIRNA THERAPEUTICS2950 WILDERNESS PLACE BOULDER CO 80301

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beigelman, Leonid Longmont, CO 390 10741
McSwiggen, James Boulder, CO 332 8520
Usman, Nassim Lafayette, CO 82 3245

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