Cyclic single-chain trispecific antibody

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United States of America Patent

APP PUB NO 20050175606A1
SERIAL NO

10474345

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a cyclic single-chain trispecific antibody against human tumor. It comprises three parts. The first part is an anti-tumor Fab antibody, an anti-tumor single-domain antibody or an scFv. The second part is a reshaped Fab antibody against human CD3, a reshaped single-domain antibody against human CD3 or a reshaped scFv against human CD3. The third part is a reshaped Fab antibody against human CD28, a reshaped single-domain antibody against human CD28 or a reshaped scFv against human CD28. The present invention also offers the DNA sequence coding for this trispecific antibody, expression vectors containing this DNA sequence and host cells (E. coli) containing the vectors.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF GENETICS CASDA TUN ROAD ANWAI BEIJING 100101
DONGGUANG HAOFA BIOTECHNOLOGY DEVELOPMENTAL CO LTD10 XINGYE RD CENTRAL DISTRICT SHATIAN TOWN DONGGUANG GUANGDONG 23980 P R
BEIJING ABT GENETIC ENGINEERING TECHNOLOGY CO LTDBEIJING 102206

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Ju-Long Beijing, CN 1 43
Gu, Ying Beijing, CN 40 113
Huang, Hua-Liang Beijing, CN 1 43
Lin, Qing Beijing, CN 49 1001
Song, Li-Ping Beijing, CN 1 43
Wang, Xiang-Bin Beijing, CN 1 43
Zhang, Zhong Beijing, CN 239 6101

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