Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
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United States of America Patent
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Issued Date -
Aug 4, 2005
app pub date -
Mar 24, 2005
filing date -
Feb 15, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
This invention features a compound of the following formula: T-(-L-C).sub.m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
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