Method for characterizing metabolic stability of a drug
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United States of America Patent
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Issued Date -
Aug 4, 2005
app pub date -
Dec 17, 2004
filing date -
Dec 17, 2003
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Abstract
An NMR based method for characterising the metabolic stability of a drug candidate comprising the steps of enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed 'hyperpolarisation'), contacting the drug candidate with liver cells or cell organelles, and carrying out NMR analysis.
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