Screening assays using intramitochondrial calcium
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United States of America Patent
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Issued Date -
Aug 4, 2005
app pub date -
Oct 26, 2004
filing date -
Jan 14, 2000
priority date (Note) -
Abandoned
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Abstract
The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.
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