Process for the preparation of tablets from pharmaceutically active substances having unfavourable tabletting properties with a granulating liquid comprising microcrystalline cellulose
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United States of America Patent
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Issued Date -
Jul 28, 2005
app pub date -
Mar 19, 2005
filing date -
Apr 29, 2002
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Abandoned
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Abstract
The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30% of microcrystalline cellulose--90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.
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