Anticancer agents using vero toxin variants
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United States of America Patent
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Issued Date -
Jul 28, 2005
app pub date -
Aug 3, 2004
filing date -
Feb 4, 2002
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Abandoned
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Abstract
An attenuated verotoxin comprising a verotoxin A subunit amino acid sequence in which at least one of the amino acids at positions 167 to 172 and positions 202 to 207 from the N terminus is mutated; an attenuated verotoxin A subunit thereof; a complex of the A subunit with a ligand; an anticancer agent using the verotoxin, A subunit or ligand; a method for treating cancer; a gene that encodes the attenuated verotoxin or its A subunit; a gene therapy agent using the gene; and a gene therapy method.
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