Humanized antibodies to CD38

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United States of America Patent

SERIAL NO

10965585

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a monoclonal antibody, preferably, with specificity for CD38, having CDRs of foreign origin and a recipient framework region having a sequence of human or primate origin, wherein the original amino acid residues in position 29 and/or 78 of the sequence of the recipient framework region of the heavy chain is replaced by a replacement amino acid residue that is the same or similar to that in the corresponding position of the sequence of the corresponding framework region of the heavy chain of the antibody from which the CDRs are derived. Method of preparation of said antibody. Pharmaceutical composition containing said antibody. Use of said antibody for the treatment of cancer and autoimmune diseases.

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Patent Owner(s)

Patent OwnerAddress
THE WELLCOME FOUNDATION LIMITEDUNICORN HOUSE 160 EUSTON ROAD LONDON NW1 2BP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ellis, Jonathan Henry Stevenage, GB 51 481
Lewis, Alan Peter Stevenage, GB 53 492

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