Humanized antibodies to CD38
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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app pub date -
Oct 14, 2004
filing date -
Dec 2, 1994
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Abandoned
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Abstract
The present invention relates to a monoclonal antibody, preferably, with specificity for CD38, having CDRs of foreign origin and a recipient framework region having a sequence of human or primate origin, wherein the original amino acid residues in position 29 and/or 78 of the sequence of the recipient framework region of the heavy chain is replaced by a replacement amino acid residue that is the same or similar to that in the corresponding position of the sequence of the corresponding framework region of the heavy chain of the antibody from which the CDRs are derived. Method of preparation of said antibody. Pharmaceutical composition containing said antibody. Use of said antibody for the treatment of cancer and autoimmune diseases.
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