Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant
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United States of America Patent
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Issued Date -
Jul 7, 2005
app pub date -
Nov 26, 2004
filing date -
Jun 28, 2002
priority date (Note) -
Abandoned
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Abstract
Composition comprising (1) a non-peptide renin inhibitor which is poorly soluble to readily soluble in water and (2) at least one physiologically tolerated anionic surfactant, at least one physiologically tolerated amphoteric surfactant at least one physiologically tolerated neutral surfactant, or a mixture of at least two of these surfactants, with the quantity of readily soluble renin inhibitor being at least 10% by weight, and the quantity of a poorly soluble renin inhibitor being at least 35% by weight based on the composition. In oral administration forms, the composition exhibits increased bioavailability.
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