Knockout mouse
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United States of America Patent
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Issued Date -
Jun 30, 2005
app pub date -
Sep 17, 2004
filing date -
Sep 19, 2003
priority date (Note) -
Abandoned
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Abstract
A knockout mouse whose genome includes an inactivated CRTH2 gene. The knockout mouse is obtained by subjecting to a serial passage a chimeric mouse originating from an early embryo to which a CRTH2-gene-knocked-out mouse embryonic stem cell has been introduced. Also disclosed is a detection method which includes employing, as an index, pathological condition of the knockout mouse to which the test substance has been administered, to thereby detect, in vivo, characteristics of a test substance in relation to CRTH2, or functions of CRTH2 in the living body.
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