Method for separating unmodified hemoglobin from cross-linked hemoglobin
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United States of America Patent
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app pub date -
Mar 3, 2005
filing date -
Jun 7, 1995
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Abstract
A method for separating unmodified hemoglobin from cross-linked hemoglobin in a hemoglobin solution. The method involves contacting the hemoglobin solution with a least one dissociating agent to form a dissociation solution wherein unmodified tetrameric hemoglobin is dissociated to form hemoglobin dimers. The hemoglobin dimers are then separated from the dissociation solution, while retaining the cross-linked hemoglobin in the dissociation solution.
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