Scan pipelining for sensitivity improvement of orthogonal time-of-flight mass spectrometers

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United States of America Patent

APP PUB NO 20050133712A1
SERIAL NO

11016336

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Abstract

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Methods and apparatus for analyzing ions by pipelining data acquisitions with an orthogonal time-of-flight (OTOF) mass spectrometer. A predetermined push sequence is established for launching packets of ions from a source region into a flight tube towards a detection region within the OTOF mass spectrometer such that ions which are launched in adjacent packets do not overlap prior to reaching the detection region. These discrete packets of ions do not intermingle and are launched in accordance with the predetermined push sequence along a propagation path from the source region toward the detection region such that portions of the packets of ions are simultaneously in-flight within the flight tube of the OTOF mass spectrometer. The times of arrival of ions are detected at the detection region to produce time-of-flight scans with signals corresponding to times of arrival for the ions in the launched packets of ions to provide a mass spectrum derived from pipelined data acquisitions.

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Patent Owner(s)

Patent OwnerAddress
NORVIEL VERN1155 EL ABRA SAN JOSE CA 95125

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Belov, Mikhail Burlingame, CA 11 209
Foley, Peter Los Altos, CA 51 371

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