Angiogenesis inhibitors
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United States of America Patent
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Issued Date -
Jun 16, 2005
app pub date -
Sep 16, 2004
filing date -
Mar 8, 2002
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Abstract
Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds. 1 In formula (I), R represents a methyl group or an ethyl group, R.sup.1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R.sup.2 represents a hydroxyl group, or R.sup.1 and R.sup.2 taken together form an epoxy ring structure.
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