Prodrugs activated by targeted catalytic proteins
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United States of America Patent
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Nov 3, 2003
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Aug 5, 1991
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Abstract
Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
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