Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
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United States of America Patent
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Issued Date -
Jun 2, 2005
app pub date -
Jan 7, 2005
filing date -
Feb 11, 2002
priority date (Note) -
Abandoned
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Abstract
A sustained/controlled release formulation with reduced risk of dose dumping and side effects combines two components: component (a) comprises a pharmaceutically active agent and a water-insoluble, but water-permeable polymer, whereas component (b) comprises a pharmaceutically active agent and a hydrophobic material. By changing the ratio of a pharmaceutically active agent and water-insoluble, but water-permeable polymer comprised in the component (a) and/or the ratio of the pharmaceutically active agent and hydrophobic material comprised in the component (b), and ideal release rate, with reduced risk of dose dumping and side effects, can easily be achieved.
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