Process for producing optically active sulfoxide derivative
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United States of America Patent
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Issued Date -
May 19, 2005
app pub date -
Nov 17, 2004
filing date -
Mar 12, 2002
priority date (Note) -
Abandoned
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Abstract
A process for preparing an optically active sulfoxide derivative (I) having CCR5 antagonism without causing side reactions such as racemization and Pummerer rearrangement, which comprises reacting a compound (II) with a compound (III) as shown by the following scheme: 1 wherein R.sup.1 represents hydrogen, an aliphatic hydrocarbon group or an aromatic group; R.sup.2 represents halogeno, alkyl, hydroxyl, amino, an aromatic group, etc.; R.sup.3 represents a 5- or 6-membered ring; R.sup.4 represents hydrogen, alkyl, alkoxy or halogeno; R.sup.5 represents hydrogen, a hydrocarbon group, a heterocyclic group, acyl, etc.; ring A represents an optionally substituted benzene ring; X represents a bond or divalent group comprising a linear part constituted of 1 to 4 atoms; m represents an integer of 1 to 5; n represents an integer of 0 to 3; p represents an integer of 0 to 2; and *.sup.1 represents an asymmetric center.
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