Fluoro linkers and their use as linkers for enzyme-activated drug conjugates
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
May 19, 2005
app pub date -
Dec 1, 2004
filing date -
Aug 10, 2001
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
The present invention provides compounds or formula (1) R.sub.1--HN--CH.sub.2--CF.sub.2--(CH.sub.2).sub.l--CR.sub.3R.sub.4--CO--R-.sub.2, wherein: l is 0, 1 or 2, R.sub.1 is a labile amino protecting group, R.sub.2 is hydroxy group or the residue or an activated ester or halogen atom; R.sub.3 and R.sub.4 are independently hydrogen atom or C.sub.1-C.sub.4 alkyl chain. There are also provided their preparation and the water-soluble conjugates based on these linkers, endowed with selective anticancer activity.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully