Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital X-ray system during thermotherapy

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United States of America Patent

SERIAL NO

10727137

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Abstract

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A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays that passed through the volume of tissue, generating a first X-ray image signal from the portions of X10 rays of the first beam detected, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays that passed through the volume of tissue during the illuminating with the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume of tissue due to the application of heat.

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Patent OwnerAddress
UNIVERSITY OF MIAMI OFFICE OF TECHNOLOGY TRANSFER1400 N W 10TH AVENUE SUITE 906 MIAMI FL 33136

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Denham, David B Miami, FL 4 61
Gonzalez-Cirre, Xochitl Madrid, ES 4 61
Manns, Fabrice Coral Gables, FL 18 368
Milne, Peter Miami, FL 5 62
Parel, Jean-Marie Miami Shores, FL 41 2139
Robinson, David S Kansas City, MO 11 157

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