Compounds comprising pseudo-amino acids
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United States of America Patent
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Issued Date -
May 5, 2005
app pub date -
Sep 24, 2004
filing date -
Mar 25, 2002
priority date (Note) -
Abandoned
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Abstract
This invention relates to compounds, and in particular to polypeptides, their use and methods for their production. The polypeptides are produced from 'pseudo-cystein' amino acids that facilitate the assembly of polypeptides by native chemical ligation. The invention provides a compound comprising a polypeptide, the polypeptide having at a C-terminal end a pseudo amino acid, the pseudo amino acid having a side chain containing a 1-amino-2-thiol moiety. For example the polypeptide comprises the structure: formula (I) wherein: R is a polypeptide chain; X is a linker.
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