5'-and 3'-capped aptamers and uses therefor
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United States of America Patent
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Issued Date -
May 5, 2005
app pub date -
Aug 6, 2004
filing date -
Aug 8, 2003
priority date (Note) -
Abandoned
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Abstract
The invention provides compositions and methods for the treating disease using aptamers having 5'-5' and 3'-3' inverted nucleotide capped ends. In particular, the invention provides 5'-5' and 3'-3' capped anti-VEGF aptamers for the treatment of neovascularization-related diseases and disorders including age-related macular degeneration.
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