Representative SNP selection method
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United States of America Patent
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Issued Date -
May 5, 2005
app pub date -
Sep 10, 2004
filing date -
Sep 10, 2003
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Abstract
Multi-dimensional scaling is used to solve characteristic polynomials of similarity matrixes, in order to determine a minimal-number SNP set (htSNPs (haplotype-tagging SNPS)) for identifying an arbitrary number of haplotypes in blocks with strong linkage disequilibrium. Thus, unnecessary SNP typing in blocks with strong linkage disequilibrium can be avoided.
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