Polymeric compounds

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United States of America Patent

APP PUB NO 20050090651A1
SERIAL NO

10491216

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a process for forming a compound having the formula (I): from chemical entities native [A], native [B] and native [C], where native [A] has a thioester group, native [B] had a 1-amino-2-thiol group with an unoxidised sulfhydryl side chain, and native [C] had a thiol reactive function (TRF) group, wherein chemical entities [A], [B] and [C] are covalently linked by linker group L, comprising the steps of: (i) admixing native [A] and native [B] in a reaction solution; (ii) condensing the unoxidised sulfydryl side chain of native [B] with the thioester group of native [A] for producing a first intermediate compound wherein [A] and [B] are linked with a .beta.-aminothioester bond; (iii) rearranging the .beta.-aminothioester bond for producing a second intermediate compound wherein [A] and [B] are linked with an amide bond having attached thereto a free thiol group; (iv) admixing native [C] with the second intermediate compound in a reaction solution; and (v) reacting the thiol reactive function (TRF) group of native [C] with the free thiol group of the second intermediate compound for producing a compound having the formula (I).

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Patent Owner(s)

Patent OwnerAddress
ADPRO TECH LIMITED243 KINGHTSBRIDGE LONDON SW7 1DN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Betley, Jason Richard Essex, GB 21 169
Esser, Dirk Essex, GB 9 41
Smith, Richard Anthony Godwin Essex, GB 13 35

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